TNFSF10 and cancer: Although the precise mechanism accounting for IFN-γ-induced suppression of TRAIL-signaling beyond activation of STAT proteins in RA-FLS remains unknown, several more recent studies have addressed other aspects of apoptosis resistance in continuously proliferating cancer cells induced by INF-γ, Thus, Bonmort et al. [126] showed that DCs also synthesize INF-γ.