Despite the potential that these cellular events could be targeted for intervention in inflammatory arthritis, recent attention has been mainly focused on the critical role of tumor necrosis factor- (TNF-) related apoptosis-inducing ligand (TRAIL) as a target for elevating the frequency of apoptosis in immune-mediated inflammatory cells primarily because agonist TRAIL-receptor-specific antibodies have shown encouraging results in promoting apoptosis in cancer cells in some clinical trials [122]. This evidence concerns the gene TNFSF10 and cancer.