CASP8 and medulloblastoma: In that regard, Häcker et al. [127] showed that inhibitors of histone deacetylase activity, including, valproic acid, suberoylanilide hydroxamic acid/Vorinostat, and MS-275 cooperate with IFN-γ to upregulate caspase-8 in medulloblastoma cells lacking caspase-8, and restore TRAIL-mediated cytotoxicity.