GPT and Hepatic fibrosis: While investigators initially focused on a combination of laboratory tests such as reversal of aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio or AST/platelet ratio index (APRI), more recently there has been a concerted effort to identify novel markers of fibrosis, necroinflammation and steatosis.[14–18] A recent systematic review of noninvasive biomarkers by Poynard et al[19] identified a total of 2237 references between 1991 and 2008 to novel biomarkers of liver fibrosis, of which 14 have been validated.