Initially, simple noninvasive indexes, such as AST/ALT ratio, platelet count, age-platelet index and APRI were evaluated and found to have moderate diagnostic accuracy for the prediction of significant fibrosis or cirrhosis.[14, 78, 79] APRI, which is the more accurate of these simple indexes, was reported to provide a moderate to high degree of accuracy (55%-80% agreement with liver biopsy) in identifying the presence of significant fibrosis and cirrhosis in patients with chronic hepatitis C or B.[79, 80]. This evidence concerns the gene GPT and fibrosis.