On applying Pearson correlation, serum PON1 activity correlated positively with HDL-C in patients with sepsis (r=0.633, P<0.05), left ventricular failure patients (r=0.814, P<0.05) and negatively with acute viral hepatitis patients (r=– 0.528, P<0.05). The gene discussed is PON1; the disease is viral hepatitis.