Furthermore, Ferré et al. demonstrated that there was a significant change in PON1 activity in patients with cirrhosis but our results are contradictory, as we found no significant change in its activity.[1] In our study, there was no significant decrease in the PON1 activity in patients with cirrhosis, leptospirosis and left ventricular failure patients, but there was a significant decrease in HDL-C levels in these patients. This evidence concerns the gene PON1 and leptospirosis.