PON1 and Cirrhosis: A previous study has stated that decrease in PON1 activity in patients with chronic liver diseases such as chronic hepatitis and cirrhosis, was related to degree of liver damage.[1] Recently, Keskin et al. also have reported reduced baseline and stimulated PON1 and arylesterase (ARE) activities in patients with chronic liver disease.[32] Contradictory to the above study, we have observed that there was lowered PON1 activity in acute viral hepatitis but normal PON1 activity in patients with cirrhosis.