A previous study has stated that decrease in PON1 activity in patients with chronic liver diseases such as chronic hepatitis and cirrhosis, was related to degree of liver damage.[1] Recently, Keskin et al. also have reported reduced baseline and stimulated PON1 and arylesterase (ARE) activities in patients with chronic liver disease.[32] Contradictory to the above study, we have observed that there was lowered PON1 activity in acute viral hepatitis but normal PON1 activity in patients with cirrhosis. Here, PON1 is linked to viral hepatitis.