IPEX comprises Immunodeficiency, Polyendocrinopathy, Enteropathy, and occurs as an X-linked Mendelian trait.[72] It is a unique syndrome caused by mutation in FOXP3, a gene encoding putative deoxyribonucleic acid (DNA)-binding protein of the forkhead family, which acts as transcriptional repressor and key modulator of regulatory T cell function.[72–75] Skin manifestations and other autoimmune phenomena are associated with this syndrome.[74–75] This rare immunodeficiency confers predisposition to infections commonly with Enterococcus and Staphylococcus.[75]. The gene discussed is FOXP3; the disease is immune system disorder.