Although high-expression of LMP1, p-P70S6K and p-4EBP1 was associated with poor survival of NPC patients, multivariate analysis revealed that only LMP1 expression (p = 0.013), as well as gender (p = 0.014) and metastasis (p = 0.003), were independent prognostic factors. This evidence concerns the gene RPS6KB1 and nasopharyngeal carcinoma.