This is further supported by the fact that the hazard ratio for GSTP1 methylation decreased when the operation status was taken into account indicating that those tumours that increased further or at least did not regress during neoadjuvant treatment were more often unmethylated for GSTP1 while FOXC1 hazard ratio increased as would be expected for a treatment independent effect. The gene discussed is GSTP1; the disease is neoplasm.