ESR1 and breast carcinoma: Epidemiologic studies have found a significant correlation between ER+ breast cancer cells and several lifestyle risk factors, such as higher body mass index, earlier age at menarche, nulliparity, and diet.[1–3] Cho et al. studied the association between dietary fat intake and breast cancer in premenopausal women and found a strong correlation between fat intake and the elevated risk of ER+ breast cancers.[4]