Sirtinol inhibition of SIRT1 did not attenuate RES-mediated resistance to oxidative stressors in cerebellar granule neurons (CGN) in culture [1], and similarly had no effect on RES’s ability to ameliorate plaque formation in a transgenic model of Alzheimer’s disease [11]. Here, SIRT1 is linked to early-onset autosomal dominant Alzheimer disease.