Whereas there were no significant differences between the drugs with regards to sexual dysfunction, prevalence of overweight, weight gain > 7% from baseline, proportions with hyperglycemia, hypercholesterolemia, low HDL concentration, high LDL concentration, triglyceride concentration, or change from baseline of these metabolic variables, change from baseline of fasting insulin, or proportion with QTc interval prolongation [27]. The gene discussed is INS; the disease is Hypercholesterolemia.