WIF1 and neoplasm: 1 and Fig. 2(A)]. The results showed that WIF-1 expression in tumor samples (0.35 ± 0.29)was significantly lower compared with normal brain tissues (0.90 ± 0.06, P < 0.001). Significant association was found between WIF-1 mRNA downregulation and the pathological grade(P= 0.001). However, WIF-1 gene expression was not correlated with age(P = 0.23)or sex(P = 0.50) in tumor samples (Tab. 2).