Furthermore, a substantially larger number of modified HABPs has to be included in a fully effective, multiepitopic, multistage, minimal subunit-based, chemically synthesized antimalarial vaccine capable of conferring protection to ALL different HLA-DRβ1* alleles, and variants, even more considering that the parasite employs multiple molecules and invasion mechanisms [34], the majority of which display a large number of exquisite genetic variations to evade the host's immune system pressure that are able to distract the complete immune system b y displaying just one amino acid variation [35]. The gene discussed is HLA-DRB1; the disease is acute lymphoblastic leukemia.