The results demonstrate, at the atomic level, that this first sterilizing-immunityinducing antimalarial peptide fits inside the specifically modified HLA-DRβ1*0403-24112–HA1.7 TCR complex, displaying a completely different pattern from that of monkeys carrying a different HLA-DRβ1*-like genotype that were not protected, thereby demonstrating that immunogenicity and induction of sterilizing immunity against transmissible diseases, like malaria, requires for specifically modified HABPs to fit appropriately inside the PBR of MHCII molecules so as to be specifically recognized by the TCR. The gene discussed is HLA-DRB1; the disease is infectious disease.