Bearing in mind that the 24112 modified peptide induced high immunogenicity and sterilizing immunity in 67% of HLA-DRβ1*0403-like genotyped monkeys, these data clearly suggest that additional modified HABPs should be included in a vaccine formulation in order to activate more TCR/pMHCII complexes and to develop complete protection against malaria in HLA-DRβ1*0403 individuals. The gene discussed is HLA-DRB1; the disease is malaria.