GSTP1 and hepatocellular carcinoma: The G allele of GSTP1 induced the replacement of isoleucine (Ile) with valine (Val) and substantially reduced GSTP1 enzyme activity [24,25], increased the risk of DNA mutation [14,15], and resulted in poor elimination of hydrophilic metabolites [4-6], consequently increasing the susceptibility to HCC when individuals are exposed to carcinogens [9]; 2) Aging was an important risk factor for HCC development [38-40].