AFP and hepatocellular carcinoma: In this study, we estimated the roles of these two gene polymorphisms on the clinical status, such as clinical stage, tumor size, lymph node metastasis, distant metastasis, Child-Pugh grade, and the serum expression levels of liver-related clinical pathological markers, such as alpha-fetoprotein, AST, and ALT, as well as the ratio of AST to ALT in HCC patients.