The LEDGF/p75 plays multiple roles during HIV-1 infection through interaction with IN, such as protecting IN from proteasomal degradation [5], potentially affecting the nuclear transport of IN [5,14], stabilizing IN as a tetramer [15], enhancing IN enzymatic activities [16,17] and, most strikingly, serving as the IN-to-chromatin tethering factor driving PICs to transcriptionally active regions of host chromosomes [5,14]. This evidence concerns the gene PSIP1 and HIV-1 infection.