REN and hypertensive disorder: We also explored stratification by blood pressure categories [Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VII) categories for all participants, binary optimal/suboptimal blood pressure, binary hypertensive/not hypertensive] (Chobanian et al. 2003) and use of medications important in the renin-angiotensin system or inflammatory pathways (ACE inhibitors, ARBs, aspirin, and NSAIDs) to determine whether these were groups particularly susceptible to this interaction.