Furthermore, it was also shown that non-lethal (P.c.chabaudi) infection up- (CYP2a5) and down- (CYP1a and 2b) modulates CYP activities in the liver of DBA-2 and C57BL/6 mice on the day, and/or shortly before or after the day on which parasitaemia peak was recorded. Here, PPIG is linked to infection.