PTGDS and obesity due to melanocortin 4 receptor deficiency: We show that the CR increased the expression levels of anti-inflammatory genes Il-10 and Adrbk1 (Fig. 3B and 3D) and energy homeostasis-related genes such as Ptgds (Fig. 6A), Lpin2 (Fig. 7A), Angptl6 (Fig. 7D), Kcnj11 (Fig. 6B), and Dusp9 (Fig. 8A) but were not affected by obesity in HF mice.