We show that the CR increased the expression levels of anti-inflammatory genes Il-10 and Adrbk1 (Fig. 3B and 3D) and energy homeostasis-related genes such as Ptgds (Fig. 6A), Lpin2 (Fig. 7A), Angptl6 (Fig. 7D), Kcnj11 (Fig. 6B), and Dusp9 (Fig. 8A) but were not affected by obesity in HF mice. Here, PTGDS is linked to obesity disorder.