Recently, Pasotti et al. have shown that dilated cardiomyopathies caused by LMNA gene defects are highly penetrant, have adult onset, are malignant conditions characterized by a high rate of severe left ventricular dysfunction and life-threatening arrhythmias, that should lead to considering special indications for ICD implantation in this group of patients [4]. Here, LMNA is linked to cardiac arrhythmia.