In murine AIA, significant and temporal changes in cytokines (IL-1β, TNFα, IFN-γ, IL-6) and factors that govern extracellular matrix turnover (MMP-3, MMP-13, TIMP-1) occur during the acute phase, Days 1 to 3 after arthritis induction [25,35,36]. Here, TIMP1 is linked to arthritic joint disease.