Thirty two days after the intravenous inoculation of tumor cells into nude mice, radiographic analyses revealed that animals bearing MDA-B02-ATX clones exhibited a 40% to 70% increase in the extent of osteolytic lesions, as compared to that seen with MDA-B02-NPP1 clones and parental cells (Figure 2A). This evidence concerns the gene ENPP1 and neoplasm.