Intriguingly, upregulation of autotaxin gene was reported in a large variety of cancers such as glioblastoma [19], aggressive neuroblastoma [20], non small cell lung cancer [21], uveal melanoma associated with poor prognosis [22], thyroid carcinoma [23], hepatocellular carcinoma with metastases [24], and breast cancer [16]. This evidence concerns the gene ENPP2 and cancer.