Thereafter, a significant increase in lung weight (LW) to BW ratio and atrial weight (AW) to BW ratio was observed at 8 weeks (Fig. 2A), which was concomitant with a marked increase in atrial natriuretic factor (ANF) expression (Fig. 2B), suggesting the transition from hypertrophy to heart failure. The gene discussed is NPPA; the disease is hypertrophy.