IL4 and multiple sclerosis: Consistent with the present study, TSA attenuated the development of allergic airway inflammation by decreasing expression of the Th2 cytokines, IL-4 and IL-5, reduced spinal cord inflammation, demyelination, neuronal and axonal loss, and ameliorated disability in the relapsing phase of experimental autoimmune encephalomyelitis, a model of multiple sclerosis [20,21].