The biological significance of this finding in melanoma represents a compelling subject for future investigation considering that, in addition to the targets cited above (HOXA10 and MEIS1), another predicted target of miR-204 is RAB22A, a member of the RAS oncogene family, which is involved in the trafficking from endosomes to the Golgi apparatus (Internet address: http://pictar.mdc-berlin.de/cgi-bin/PicTar_vertebrate.cgi algorithm for the identification of miR target). The gene discussed is MEIS1; the disease is melanoma.