By contrast, melanoma in the younger age group would appear similar to Type I EOC cells, with high levels of IKKb expression due to low hsa-miR-199a that, when stimulated by nuclear factor-kB (NF-kB) activation, would lead to cytokine production, cell proliferation and induction of anti-apoptotic proteins as a result of the expression of an active IKKbeta pathway. This evidence concerns the gene IKBKB and melanoma.