Thehistopathological and immunohistochemical result was ‘liver biopsy fragment with neoplastic infiltrationof well–differentiated adenocarcinoma, citokeratin 7 and CA 125 positive in tumor cells, citokeratin 20 and19 negative in tumor cells, OCH1E5 positive in the normal hepatocytes, negative in tumor cells, CDX2negative, synaptophysin negative, chromogranin negative’ (Fig 4,Fig 5,Fig 6). This evidence concerns the gene SYP and neoplasm.