It was demonstrated that the absence of the skeletal muscle specific calpain 3 (from the corresponding gene capn3) causes limb girdle muscular dystrophy type 2A (LGMD2A) [4], a disease that has been linked to a significant level of apoptotic fibres [5]. Here, CAPN3 is linked to autosomal recessive limb-girdle muscular dystrophy type 2A.