JNK and p38 may have pro-apoptotic effects that include the activation of FOXO1, which is consistent with our previous finding that showed that an AGE CML-collagen induces apoptosis of fibroblasts through RAGE signaling and activation of p38 and JNK MAP kinase pathways [22]. This evidence concerns the gene FOXO1 and chronic myelogenous leukemia, BCR-ABL1 positive.