TNF-α (20 ng/ml) increased caspase-3 activity 7.8-fold compared to unstimulated cells, while CML-collagen, compared with control collagen at a concentration of 200 μg/ml, increased caspase activity 3.2-fold (p<0.05). The gene discussed is TNF; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.