WT1 and Nephroblastoma: However, other hereditary cancer syndromes appear to have a more limited tumor spectrum.For example, individuals with syndromes such as WAGR (Wilms tumor, aniridia, genitourinary abnormalities, and mental retardation syndrome) and Denys-Drash Syndrome have mutations in the WT1 gene, and these patients are primarily at risk for Wilms tumor [2, 3].