Our laboratory identified c-Jun NH2-terminal kinase (JNK) kinase 1/mitogen-activated protein kinase (MAPK) kinase 4 (JNKK1/MKK4) as a prostate cancer metastasis suppressor in 1999 [11] and subsequently as an ovarian cancer metastasis suppressor in 2002 [12]. This evidence concerns the gene MAP2K4 and Familial prostate cancer.