Table S9 lists selected information on ligands. Several lines of evidence support a role for PPARβ/δ in psoriasis. It is upregulated in psoriatic skin [12], [13], induced by TNFα [14], [15], stimulates proliferation and blocks apoptosis in keratinocytes [16], and induces angiogenesis [17], all of which is consistent with a disease-promoting role in psoriasis. The gene discussed is TNF; the disease is psoriasis.