Apart from interferon response genes, the other major difference in gene expression between psoriasis and the phenotype in PPARβ/δ mice is terminal epidermal differentiation, which is blocked in psoriasis, but increased in the mouse model, which confirms the established pro-differentiation activity of PPARβ/δ [52] and the fact that it triggers differentiation in wound healing [28], [53]. The gene discussed is PPARD; the disease is psoriasis.