Although the ethanol-inducible CYP2E1 and fatty acid metabolizing CYP4A P450s may be directly involved in the progression of steatosis to steatohepatitis by production of ROS and initiation of lipotoxicity, other drug metabolizing cytochrome P450 genes are dramatically affected in fatty liver disease and therefore have an important role in identification of appropriate drug treatment modalities to avoid the consequences of adverse drug reactions or drug toxicity. This evidence concerns the gene CYP2E1 and steatosis.