CYP2E1 and metabolic dysfunction-associated steatohepatitis: Numerous reports have indicated that the ethanol-inducible CYP2E1 is induced in both hepatic steatosis and steatohepatitis [6, 7] even though Cyp2e1-null mice develop steatohepatitis with a markedly increased CYP4A gene expression, suggesting that CYP4A P450 may also play an important role in the progression of NAFLD to NASH.