During NAFLD progression, CYP2E1, CYP2C19, and CYP1A2 mRNA and the corresponding P450 protein contents were decreased while those of CYP2A6, CYP2B6 and CYP2C9 mRNA and the proteins were increased [109]. This evidence concerns the gene CYP2E1 and metabolic dysfunction-associated steatotic liver disease.