Numerous reports have indicated that the ethanol-inducible CYP2E1 is induced in both hepatic steatosis and steatohepatitis [6, 7] even though Cyp2e1-null mice develop steatohepatitis with a markedly increased CYP4A gene expression, suggesting that CYP4A P450 may also play an important role in the progression of NAFLD to NASH. Here, CYP2B6 is linked to metabolic dysfunction-associated steatohepatitis.