The ethanol-inducible CYP2E1 is elevated in both rodent experimental models of steatosis and steatohepatitis and human NAFLD patients, and in vivo levels of CYP2E1 activation correlate with the severity of liver damage, suggesting that this P450 is one of the major microsomal contributors of ROS-induced hepatic injury [6, 98]. Here, CYP2E1 is linked to metabolic dysfunction-associated steatotic liver disease.