A few studies have reported that the clinical course is generally more severe in patients with HBV / HCV co-infection,[6–8] whereas a few have reported decreased severity.[16] But in the present study presence of HCV co-infection did not alter the course of CLD as no significant change in the clinical presentation and biochemical parameters was observed in patients having isolated anti-HBc IgG positivity and those also having HCV co-infection. The gene discussed is KRT88P; the disease is coinfection.