Though the role of HBV in HCV associated HCC patients who are negative for hepatitis B surface antigens (HbsAg) remains poorly defined, high prevalence of HBV markers like HBc IgG is seen in patients with HCV related chronic liver disease, particularly those with hepatocellular carcinoma, suggesting that H BV infection, probably including latent infection, may play an important role in carcinogenesis in these patients.[9]. The gene discussed is KRT88P; the disease is hepatocellular carcinoma.