Leptin is a hormone released from the adipocytes which influences energy balance, exerts long acting effects to reduce adiposity by decreasing appetite and increasing thermogenesis.[2] A glucagon level regulates orexigenic-signal terminating meals after feeding.[7] In recent study, a positive association between higher fasting plasma glucagon like peptide and fat oxidation was observed thus reducing obesity.[8] Growth hormone secretion is impaired with any secretory defect of pituitary which is proportional to degree of obesity. This evidence concerns the gene GCG and obesity due to melanocortin 4 receptor deficiency.