LCAT and coronary artery disorder: The efficiency of RCT depends on the specific ability of Apo A-I to promote cellular cholesterol efflux, bind lipids, activate lecithin: cholesterol acyltransferase (LCAT), and form mature HDL that interact with specific receptors and lipid transfer proteins.[24, 25] The APOAI gene is present along with the APOC3 and APOA4 genes, on chromosome 11(11q23.3-qter).[26] It has also been shown that the A allele of the APOAI gene contributes to the severity of CAD and low levels of HDL among Northern Indians.[27]