likely, we analyzed the patients' serum prior to initial treatment, the results indicated that the diagnostic sensitivity of CYFRA 21-1, SCC and CEA were only 45.8%, 24.2%, and 11.7%, and there were no significant correlation between CYFRA 21-1, SCC, CEA and the differentiation of esophageal squamous cell carcinomas, while the expressions of HSP72 and gp96 in esophagheal carcinoma were 93.9% and 85.0%, respectively. Here, SERPINB3 is linked to esophageal squamous cell carcinoma.