At week 16, both PAI-1 WT and PAI-1−/− mice implanted with VEGF-C expressing cells showed higher tumor incidence (P = 0.0051, P<0.0001, respectively; Fig. 1B) and, in PAI-1 WT mice, a tendency to a higher tumor volume (P = 0.1513; Fig. 1C) than mice inoculated with mock MCF7 cells. This evidence concerns the gene SERPINE1 and neoplasm.