The fact that gain of the BPTF locus and up-regulation of the BPTF gene epitomize many human cancers indicates that our cellular model with a defined 17q24.3 translocation located within BPTF causing an elevation in endogenous BPTF could shed light on cancer-associated 17q translocations and that BPTF could be an important player in development of those malignancies. Here, BPTF is linked to cancer.