Importantly, in 67% of the BPTF-positive lung tumors cases, gain of the 17q24.3 locus was associated with poor prognosis (grade III), while only 37% of the cases were graded either II or I. Regarding the other tumor types, grading was either not available (neuroblastomas, nephroblastomas, leukemias, retinoblastomas) or was not significant due to small sample size. The gene discussed is BPTF; the disease is retinoblastoma.