Statins inhibit the rate-limiting enzyme of the mevalonate (MVA) pathway, HMG-CoA reductase (HMGCR), and have been used for decades as safe and effective agents in the control of hypercholesterolemia[7,8] In addition to cholesterol, the MVA pathway gives rise to a number of crucial biochemical end-products, including ubiquinone, dolichol, isopentenyladenine, and isoprenoid precursors. This evidence concerns the gene HMGCR and familial hypercholesterolemia.