They have prostate issues, and they go to bathroom too often, they have arthritis, they have difficulty to get to the bathroom...some they had problems with hypokalemia or renal issues that they were not a candidate for the medication...and, uh, my patients are diabetic, they have coronary artery disease, they have, you know, metabolic syndrome, so I think ACE inhibitors and ARBs are more selective for them than you know, just, uh, hydrochlorothiazide.' Here, ACE is linked to arthritic joint disease.