In our study, we first analyzed the expression of Robo1, Robo2, Robo3, Slit1, Slit2, and Slit3 in the SF of patients with RA and continued to evaluate the influence of Robo3 expression and effects of Slit3 on RASF as a potential therapeutic tool. The gene discussed is SLIT3; the disease is rheumatoid arthritis.