EGF and malaria: A portion of the MSP1 targeted by protective immunity antigen has been mapped to the 19 kDa carboxy-terminal region (MSP1-19) which contains two tandem repeat epidermal growth factor (EGF)-like domains while the most C-terminal of the disulphide-bonded domains in AMA-1 (Domain III) was also a target for inhibitory antibodies isolated from malaria patients [16-20].