It has also been shown that translation of COX-2 mRNA requires the activity of the eIF-5A transcription factor (Parker and Gerner, 2002), the inhibition of which impairs murine melanoma growth (Jasiulionis et al., 2007) and that basal COX-2 expression in melanoma cells is associated with malignant transformation (Kuźbicki et al., 2006). This evidence concerns the gene PTGS2 and melanoma.