Gain at 8q, resulting in amplification of the oncogene c-Myc (Issing et al, 1993), was also consistently identified, as was gain at chromosome 20, a specific marker of HPV-associated cancer that has been reported to result in elevated mRNA levels of the de novo DNA methyltransferase DNMT3B at 20q (Wilting et al, 2006). Here, DNMT3B is linked to cancer.