A similar configuration has been observed between FGFR4, N-CAM and N-cadherin in tumour cell migration (Cavallaro et al, 2001), providing a mechanistic explanation of the impact FGFR4 has on several tumour types (Stadler et al, 2006; Streit et al, 2006). The gene discussed is FGFR4; the disease is neoplasm.