Moreover, functional studies in a KRAS mutant CRC murine model has confirmed MKP-3 high levels, and high MKP-2 and MKP-3 expressions have been described in human tumour biopsy samples from mutant KRAS CRC patients (Haigis et al, 2008; De Roock et al, 2009). This evidence concerns the gene DUSP4 and neoplasm.