The updated analysis demonstrated an additional TP53 mutation: 659A>G in a family fulfilling LFS criteria, four further BRCA1 mutations (2682C>T, del exons 1–17, del exons 5–17, 1953DupG) in four familial breast cancers and 1 BRCA2 mutation (1058C>A) out of the 15 additional samples obtained since our last report (Lalloo et al, 2006). Here, TP53 is linked to breast cancer.