Of the 186 colorectal adenocarcinoma samples analysed, 29 (15.6%) harboured a mutation in BRAF. All BRAF mutations were the V600E type due to T to A transversion in exon 15, although a previously reported synonymous SNP (rs56101602) was detected in one adenocarcinoma sample in exon 11. This evidence concerns the gene BRAF and colorectal adenocarcinoma.