This confirms and extends observations from 111 men in the expectant management cohort from Örebro where men with ERG rearranged prostate cancer were significantly more likely to have lethal disease than men with fusion negative tumors (cumulative incidence ratio = 2.7, p-value < 0.01, 95% CI = [1.3,5.8]) [50]. Here, ERG is linked to Familial prostate cancer.