Though it has been reported that IL-1β exerts inhibitory effects on murine ATDC5 chondrocyte dynamics and metatarsal longitudinal growth [15], recent observation suggested that overgrowth arthropathy in CINCA/NOMID is not driven by IL-1β, but such overgrowth may be due to abnormal apoptosis at the site of enchondral ossification as NALP3 is expressed in cartilage [16,17]. This evidence concerns the gene IL1B and CINCA syndrome.