BMP4 and age-related macular degeneration: Noggin significantly inhibited VEGF-Asecretion by about 40% under our experimental conditions thereby confirming arole for BMP-4 in stimulating VEGF-A secretion (p<0.05; data not shown).Recently, it was shown that in AMD patients with CNV, the RPE in CNV lesionsshowed essentially absent immunohistochemical levels of expression of BMP-4suggesting that lack of BMP-4 may be permissive for pathologic angiogenesis[53].