Theantiangiogenic and neurotrophic growth factor, pigment epithelial derivedfactor (PEDF), and the proangiogenic growth factor, vascular endothelialgrowth factor-A (VEGF), are released from retinal pigment epithelial (RPE)cells where they play a critical role in the pathogenesis of age-relatedmacular degeneration (AMD). The gene discussed is VEGFA; the disease is age-related macular degeneration.