We also examined the effect of these IL18 variants in response to an oral fat tolerance test (OFTT) and an oral glucose tolerance test (OGTT) in young men (aged 18–28 years) in the second European Atherosclerosis Research Study (EARSII), an offspring study of ‘cases’ with a paternal history of premature coronary heart disease (CHD) with matched ‘controls’. Here, IL18 is linked to coronary artery disorder.