In GrOW, Hap6 (Frequency-2.6%) was associated with higher insulin levels (p < 0.0001), estimates of HOMA-Insulin Resistance (p < 0.0001) and HOMA-β-cell (p < 0.0001) compared to the common haplotype Hap1 (Frequency-33.2%). This evidence concerns the gene INS and Insulin resistance.