Using the same siRNAs, we performed cell growth assays and found significant growth suppression by two independent siRNAs targeting KDM5B for two bladder cancer cell lines (SW780 and RT4) and three lung cancer cell lines (A549, LC319 and SBC5) while no effect was observed when we used control siRNAs (Figure 5B). The gene discussed is KDM5B; the disease is urinary bladder carcinoma.